Single-crystal structure analysis of designer drugs circulating in the Japanese drug market by the synchrotron radiation X-ray diffraction
| Autor: | Yoshinori Nishiwaki, Shigeru Kimura, Nobuhiro Mizuno, Nobuhiro Yasuda, Ruri Hanajiri, Yuki Nakamura, Shinjiro Hayakawa, Takashi Hashimoto, Sadao Honda |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
030103 biophysics Radiation Materials science Structure analysis medicine.drug_class Synchrotron radiation Nanotechnology 010403 inorganic & nuclear chemistry Condensed Matter Physics 01 natural sciences 0104 chemical sciences Drug market Designer drug 03 medical and health sciences Crystallography Beamline medicine General Materials Science Phenmetrazine Instrumentation medicine.drug |
| Zdroj: | Powder Diffraction. 32:112-117 |
| ISSN: | 1945-7413 0885-7156 |
| Popis: | Over the past 20 years, many designer drugs derived from controlled substances have been widely distributed as easily available psychoactive substances and have become a serious problem in Japan. In order to determine the absolute structures of four new designer drugs derived from medicines (methylphenidate and phenmetrazine) X-ray single-crystal structure analyses were performed using the BL26B1 beamline of synchrotron radiation facility SPring-8. The results show that the molecular configuration of these designer drugs (having two asymmetric carbons), which were distributed in the illegal drug market had threo-forms as found for methylphenidate and phenmetrazine. |
| Databáze: | OpenAIRE |
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