| Autor: |
Menichini U, Giordano G, Fattacciu G, Malagamba D, E Rasore, Meineri I, C M Cuttica, Massimo Giusti |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
European Journal of Clinical Investigation. 28:13-19 |
| ISSN: |
0014-2972 |
| Popis: |
Background We examined the effect of growth hormone (GH) administration on the psychological capacity and sense of well-being in 25 patients with adult-onset GH-deficiency (GHD). Methods Very low dosages (0.5–1.0 UI day−1 s.c. at bed-time) of recombinant human (rh)-GH (n = 13; aged 50 ± 15 years, mean ± SD) or placebo (n = 12, 53 ± 14 years) were given at random for a 6-month period. Quality of life was assessed by using the Italian version of the self-rating Kellner Symptom Questionnaire (KSQ) and the Hamilton Depression Scale (HDS). Results No difference in insulin-like growth factor I (IGF-I) levels was noted between groups on entry to the study. A significant increase in IGF-I (month 0 56.2 ± 10.4 μg L−1 vs. month 6 125.7 ± 16.7 μg L−1; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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