Inhibition of human leukocyte elastase. 6. Inhibition by 6-substituted penicillin esters
| Autor: | Shrenik K. Shah, Pam S. Dellea, Paul E. Finke, James B. Doherty, Kevan R. Thompson, Karen M. Hand, D. S. Fletcher, Alan L. Maycock, Bonnie M. Ashe, Mary Ellen Dahlgren |
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| Rok vydání: | 1993 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Clinical Biochemistry Cephalosporin Pharmaceutical Science Biochemistry chemistry.chemical_compound Pharmacokinetics Drug Discovery medicine Molecular Biology chemistry.chemical_classification Chemotherapy biology Organic Chemistry Penicillin Enzyme chemistry Enzyme inhibitor biology.protein Lactam Molecular Medicine Chemical stability sense organs medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:2283-2288 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)80940-9 |
| Popis: | Penicillin amides substituted at C-6 with either an α- or β-trifluoroacetamido or an α-alkoxy functionality are reported as human leukocyte elastase (HLE) inhibitors. The structure activity relations for these derivatives are discussed and compared to the corresponding known cephalosporin structures in terms of chemical stability, HLE inhibition, and efficacy in an intratracheal (IT) lung hemorrhage assay. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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