| Popis: |
With the view to determine the effectiveness of the usage of Probiox, an open, individually-controlled clinical bacterial trial was conducted in 40 early age children who received standard antibiotic therapy for acute non-hospital pneumonia and were divided into two groups depending from received Probiox. The third group of children (n=8), who initially did not receive probiotics, but due to the development of a manifested antibiotic-associated diarrhea (AAD) the Probiox was prescribed, was formed during the study. The extent of microbial landscape disturbances during the use of antibiotics in children was assessed by sowing the serial dilutions of faeces, the content of microflora was expressed in lg CFU/g; clinical observations and investigation of coprogramme were conducted.In children of the main group who received Probiox, on the 7–10th day of treatment a moderate decrease in the content of bifidobacteria, an increase of lactobacilli, the disappearance of a part of the opportunistic flora in the intestinal microbiome were occurred. The number of children with identified associations of conditionally pathogenic microorganisms decreased twice.The children of the group of comparison showed a significant depression of bifido- and lactobacilli, an increasing of E. coli quantity and the frequency of detection of two/three-component associations of opportunistic microorganisms, in two fold increasing of the opportunistic flora, the emergence of lactose-negative E. coli.Only 1 child of the main group had a short-term softening of the stool with moderate abdominal discomfort. Children of the comparison group had a pronounced dyspeptic syndrome in 20%, periodic abdominal pain, moderate bloating at 3-4 days after antibiotic use. In children of the additional group, the relief of AAD symptoms occurred within two days after the initiation of the use of Probiox.The obtained data testify about the clinical effectiveness of the usage of Probiox for the prevention of the disorders of intestinal microbiota and antibiotic-associated diarrhea during administration of antibiotic therapy of the acute pneumonia in early age children. High efficiency and good tolerability is also demonstrated in children with developed AAD. |
