IL-15 is required for the migration of influenza-specific effector CD8+ T cells to the lung airways (92.24)
| Autor: | Katherine Verbist, Charles Cole, Mary Field, Kimberly Klonowski |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 184:92.24-92.24 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | CD8 T cells targeted to conserved viral proteins can provide protection against multiple strains of seasonal and highly pathogenic influenza virus, mediating heterosubtypic immunity. However, in mice this protection declines over time as the number of influenza-specific CD8 T cells in the lung airways falls below a set numerical threshold, despite influenza-specific splenic memory CD8 T cells continually migrating to the lung airways. Thus, understanding how to enhance both the frequency and longevity of the Tmem population in the lung airways is critical to an effective CD8 T cell-mediated vaccine. Since IL-15 regulates the survival of anti-viral CD8 Tmem, we sought to determine whether local deficiencies in IL-15 were responsible for the attrition of influenza-specific CD8 T cells in the lung airways. Using wild type and IL-15 deficient animals, we found IL-15 to be dispensable for both the generation and maintenance of influenza nucleoprotein (NP)-specific CD8 Tmem in all tissues. However, IL-15-/- mice harbored fewer influenza-specific CD8 Teff cells in the airways. Furthermore, influenza-specific Teff migrated to IL-15 complexes in vitro and in vivo. Overall, our studies describe a unique role for IL-15 in regulating the trafficking of CD8 Teff to the lung airways following influenza infection and suggest that using IL-15 complexes as an adjuvant in the mucosa may represent a methodology to prolong protection by lung airway-resident CD8 T cells. |
| Databáze: | OpenAIRE |
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