Nutzen und Verträglichkeit einer fixen Kombination von Clindamycin und Benzoylperoxid bei Akne vulgaris
| Autor: | I. Zschocke, K. Herberger, M. A. Radtke, S. Rustenbach, Matthias Augustin, C Blome |
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| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Aktuelle Dermatologie. 37:164-170 |
| ISSN: | 1438-938X 0340-2541 |
| DOI: | 10.1055/s-0030-1256411 |
| Popis: | BACKGROUND: The improvement in quality of life and the generation of patient benefits are major objectives in acne therapy. OBJECTIVES: Benefit assessment and tolerance-assessment of topical clindamycin + benzoyl peroxide in acne therapy in a random inspection in Germany. METHODS: Benefit assessment was raised from an open observational study with n = 906 patients being treated by 205 dermatologists. Assessment was performed at baseline, after 3 to 5 weeks (medium:4) and 10 to 12 weeks. The main endpoints where the lesion count of all acne lesions as well as the main global assessment of the patient and the physician. Quality of life was measured by the „acne disability index” and the patient-defined benefit was assessed with the „patient benefit index (PBI)”. To evaluate the tolerance, standardised questions where adressed to the physician and the patient. According to GCP/ICH-guidelines all AE and SAE were recorded and evaluated. RESULTS: All clinical outcome parameters showed a significant improvement after a treatment with topical clindamycin + benzoyl peroxide for 4 and 10 - 12 weeks (p 1) was 90.2 % after 4 weeks and 93,0 % after 10 - 12 weeks. CONCLUSION: The topical preparation of clindamycin + benzoyl peroxide is a safe and effective treatment option for patients with mild to moderate acne vulgaris. The treatment showed in a big proportion of patients a relevant improvement of patient defined benefit. |
| Databáze: | OpenAIRE |
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