Photoeradication and imaging of atheromatous plaque with texaphyrins

Autor: David Kessel, Fan Qing, Kathryn W. Woodburn, Stuart W. Young
Rok vydání: 1997
Předmět:
Zdroj: SPIE Proceedings.
ISSN: 0277-786X
DOI: 10.1117/12.275065
Popis: Cardiovascular disease is the chief cause of death in the western world. Lutetium texaphyrin (PCI-0123) is a pure, synthetic, aqueous-soluble macrocycle that localizes in both cancerous lesions and atheromatous plaque. The lutetium texaphyrin complex is a potent photosensitizer in vivo, where it is activated by tissue-penetrating far red light (720 - 760 nm). Patient diagnosis and treatment planning are possible with PCI-0123 fluorescence imaging. In this study the localization and selective eradication of atheromatous plaque using PCI-0123 and photoangioplasty are discussed.
Databáze: OpenAIRE