EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure
| Autor: | Michael J. Soskis, George Chenaux, Michael A. Robichaux, Hsin-Yi Henry Ho, Michael E. Greenberg, Mark Henkemeyer, Christopher W. Cowan |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Anterior commissure Biology Corpus callosum medicine.disease White matter 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology medicine.anatomical_structure Developmental Neuroscience Forebrain medicine Ephrin Axon guidance Receptor Agenesis of the corpus callosum Neuroscience |
| Zdroj: | Developmental Neurobiology. 76:405-420 |
| ISSN: | 1932-8451 |
| Popis: | The two cortical hemispheres of the mammalian forebrain are interconnected by major white matter tracts, including the corpus callosum (CC) and the posterior branch of the anterior commissure (ACp), that bridge the telencephalic midline. We show here that the intracellular signaling domains of the EphB1 and EphB2 receptors are critical for formation of both the ACp and CC. We observe partial and complete agenesis of the corpus callosum, as well as highly penetrant ACp misprojection phenotypes in truncated EphB1/2 mice that lack intracellular signaling domains. Consistent with the roles for these receptors in formation of the CC and ACp, we detect expression of these receptors in multiple brain regions associated with the formation of these forebrain structures. Taken together, our findings suggest that a combination of forward and reverse EphB1/2 receptor-mediated signaling contribute to ACp and CC axon guidance. |
| Databáze: | OpenAIRE |
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