Analgesic Rectal Suppositories Containing a Nonsteroidal Anti-Inflammatory Drug in Combination with a Tricyclic Antidepressant and Transmucosal Conductor

Autor:	T. G. Khonina, I. G. Zyryanova, E. V. Shadrina, L. P. Larionov, M. V. Ivanenko
Rok vydání:	2018
Předmět:	Pharmacology Active ingredient Drug 010405 organic chemistry medicine.drug_class Chemistry media_common.quotation_subject Analgesic Tricyclic antidepressant 01 natural sciences Anti-inflammatory Acute toxicity 0104 chemical sciences Ketorolac 010404 medicinal & biomolecular chemistry Drug Discovery medicine Amitriptyline medicine.drug media_common
Zdroj:	Pharmaceutical Chemistry Journal. 52:786-789
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-018-1900-8
Popis:	A composition and preparation method for new analgesic rectal suppositories containing a nonsteroidal anti-inflammatory drug (ketorolac), tricyclic antidepressant (amitriptyline), and transmucosal conductor (silicon glycerolates) as the active ingredients in a poly(ethylene glycol) (PEG-4000) base were proposed. The acute toxicity was determined and showed they were safe to use. The high analgesic activity of the suppositories was confirmed using electrical stimulation. Their high transmucosal activity in vitro was revealed by measuring the degree of diffusion of one of the active ingredients (amitriptyline) through a natural biological membrane. The results indicated that the developed suppositories could be recommended for further investigations of future medical use to relieve pain of various etiologies.
Databáze:	OpenAIRE
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