The Easy Approach to N-Hydroxy-N-cycloalkenylamides through Nitrosocarbonyl Ene Reactions to Cycloalkenes: Valuable Compounds for Antiviral Syntheses

Autor:	Paolo Quadrelli, Mattia Moiola, Misal Giuseppe Memeo, Faiq Hamasaid Hussain, Karzan Khaleel Hameed, Ahmed Anwar Amin
Rok vydání:	2018
Předmět:	010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Adduct Cyclic Alkenes chemistry.chemical_compound Molecule Organic synthesis Ene reaction
Zdroj:	Synthesis. 51:1383-1390
ISSN:	1437-210X 0039-7881
Popis:	An easy approach to N-hydroxy-N-cycloalkenylamides, ene adducts of cyclic alkenes of different sizes, is presented. The products can be obtained both through the thermal generation of the nitrosocarbonyl intermediates and via the photochemical fragmentation of the Wieland heterocycle, this being the mildest way to generate these fleeting species, also affording the best results so far in terms of chemical yields. The use of the ene reaction for the synthesis of biologically active molecules represents an interesting and valuable aspect of modern organic synthesis, and this is the strategy proposed as a remarkable alternative to current methods.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::28164ff5e547edbdf8280d1ad32c1d9b https://doi.org/10.1055/s-0037-1610845 Zobrazit plný text záznamu