Alzheimer’s disease Aβ42 peptide induces an increase in Na,K-ATPase glutathionylation
| Autor: | Vladimir A. Mitkevich, Valentina A. Lakunina, A. A. Makarov, K. M. Burnysheva, Irina Yu. Petrushanko |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification biology Reducing agent Chemistry Amyloid beta Biophysics Peptide General Chemistry General Medicine Disease Biochemistry Redox status 03 medical and health sciences 030104 developmental biology 0302 clinical medicine biology.protein Na+/K+-ATPase Thiol redox Incubation 030217 neurology & neurosurgery |
| Zdroj: | Doklady Biochemistry and Biophysics. 473:114-117 |
| ISSN: | 1608-3091 1607-6729 |
| Popis: | We have shown that the inhibition of Na,K-ATPase during its long-term incubation with amyloid beta (Aβ42), an Alzheimer’s disease protein, is caused by the change in the thiol redox status of cells leading to induction of glutathionylation α-subunit of Na,K-ATPase. To restore the activity of Na,K-ATPase, it is proposed to use reducing agents, which promote normalization of the redox status of cells and deglutathionylation of the protein. |
| Databáze: | OpenAIRE |
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