Synthesis and Antimycobacterial Activity of 5-(Hetarylmethylidene)-2,4,6-Pyrimidine- 2,4,6(1H,3H,5H )-Triones And 5-(2-Chloropropylidene)- 2,4,6-Pyrimidine-2,4,6(1H,3H,5H )-Triones

Autor:	N. M. Gabitova, M. Yu. Yushin, A. K. Ayupova, A. V. Khrapova, A. G. Tyrkov, G. N. Genatullina, L. V. Saroyants
Rok vydání:	2020
Předmět:	Pharmacology Low toxicity Pyrimidine 010405 organic chemistry Chemistry medicine.drug_class Pharmacology toxicology Dapsone Antimycobacterial 01 natural sciences Medicinal chemistry Acute toxicity 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Drug Discovery medicine medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 54:134-137
ISSN:	1573-9031 0091-150X
Popis:	Series of 5-(hetarylmethylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones and 5-(2-chloropropylidene)- 2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones were synthesized and tested for antimycobacterial activity against M. lufu and acute toxicity. The 5-(hetarylmethylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones and 5-(2-chloropropylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones were shown to possess low toxicity and antimycobacterial activity of various strengths as compared to dapsone and could be considered promising compounds for further discovery of antimycobacterial drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::280bab4e6d40e7ed0d25d2427b0980db https://doi.org/10.1007/s11094-020-02169-z Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.