Blockade by Progesterone of Estrogen—Induced LH and FSH Release in the Rhesus Monkey12
| Autor: | Ernst Knobil, G. Weiss, T. Yamaji, D. J. Dierschke, R. F. Weick, F. J. Karsch |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class media_common.quotation_subject Biology Follicle-stimulating hormone chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Estrogen Internal medicine Follicular phase medicine Estradiol benzoate Luteinizing hormone Corpus luteum hormones hormone substitutes and hormone antagonists Menstrual cycle media_common Hormone |
| Zdroj: | Endocrinology. 92:1496-1501 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-92-5-1496 |
| Popis: | The discharges of LH consequent to the administration of estradiol benzoate (EB) during the follicular phase of the menstrual cycle were blocked by acute elevations in plasma progesterone (P) concentrations to supraphysiologic levels. This eiTect of P was observed when circulating estrogens and P rose simultaneously or when P was introduced 12 hr after the EB injection. Physiologic plasma P concentrations, achieved either by a functional corpus luteum or by the implantation of P—containing Silastic capsules, also blocked the positive feedback action of estrogen on LH and FSH release. P, however, did not interfere with the negative feedback inhibition of LH and FSH secretion by estrogen. (Endocrinology 92: 1496, 1973) |
| Databáze: | OpenAIRE |
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