Endometrial carcinoma: changes to classification (WHO 2020)
| Autor: | Naveena Singh, Mariam Masood |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Neuroendocrine neoplasia medicine.medical_specialty Intestinal type Histology business.industry Mesonephric Adenocarcinoma medicine.disease Pathology and Forensic Medicine Internal medicine medicine Carcinoma Adenocarcinoma Immunohistochemistry Mucinous carcinoma business Who classification |
| Zdroj: | Diagnostic Histopathology. 27:493-499 |
| ISSN: | 1756-2317 |
| DOI: | 10.1016/j.mpdhp.2021.09.003 |
| Popis: | Since the 2014 WHO classification of Female Genital Tract tumour, there have been significant improvements in our understanding of the genomic basis of endometrial carcinoma, largely based on the seminal findings from The Cancer Genome Atlas analysis, which have been befittingly included in the newest edition for the subcategorization of endometrioid carcinomas. Nevertheless, morphological classification, with or without the aid of immunohistochemistry, remains paramount to diagnosis and correct patient management, in addition to retaining the global outreach of the 5th Classification in the absence of universal access to molecular testing. In addition to this change in subclassification of endometrioid carcinomas, four new entities have been included within the endometrial carcinoma classification: mesonephric adenocarcinoma, mesonephric-like adenocarcinoma, squamous cell carcinoma and mucinous carcinoma, intestinal type. The subject of Neuroendocrine neoplasia has merited a separate chapter under “Neuroendocrine Neoplasia of Female Genital Tract” in congruence with other body sites. This streamlines the classification and aids management of patients consistently. Additionally, more nuanced information has been included in most other subsections, including novel immunohistochemical markers and relevant prognostic factors. In this short review, we aim to describe the updates to endometrial carcinoma classification in the latest WHO edition. |
| Databáze: | OpenAIRE |
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