Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage
| Autor: | Antonio Carlos Romão Borges, Antonio Felipe Silva Carvalho, Rachel Melo Ribeiro, Elismar de Castro Marques, Fabio de Souza Monteiro, Marilene Oliveira da Rocha Borges |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology Voltage-dependent calcium channel biology Traditional medicine medicine.drug_class Chemistry Calcium channel Pharmaceutical Science biology.organism_classification Jejunum 03 medical and health sciences Atropine 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Syzygium Antidiarrhoeal medicine 030211 gastroenterology & hepatology Antispasmodic Antagonism medicine.drug |
| Zdroj: | African Journal of Pharmacy and Pharmacology. 12:11-18 |
| ISSN: | 1996-0816 |
| DOI: | 10.5897/ajpp2017.4868 |
| Popis: | Syzygium cumini L. Skeels (Myrtaceae) commonly known as jambolan is used as traditional medicine to treat gastrointestinal disorders in children in Brazil. This work is one of the first to evaluate the antidiarrhoeal and antispasmodic activity of the standardized extract of S. cumini leaves (HESc) in experimental models in vitro and in vivo rodents. Mice pre-treated with HESc (100, 250 and 1000 mg/kg) and atropine (1.0 mg/kg) had reduced intestinal transit velocity of 11.0; 23.2 and19.1%, respectively compared to saline control (46.6±0.9). In isolated rats jejunum, HESc (50, 150 and 300 µg/mL) shifted to the right cumulative concentration-response curves to ACh with changing maximum effect (Emax), which is characteristic of non-competitive antagonism to ACh. HESc also promoted relaxation (Emax 90.2±5.8%) in preparations pre-contacted with KCl (75 mM). Additionally, it reduced the maximal CaCl2-induced response in 15.4; 56.3 and 92.1% in a concentration-dependent manner. The study results show that HESc has an antidiarrhoeal and spasmolytic potential that can be partly explained by the reduction of intestinal transit velocity and blockage of the voltage-dependent calcium channels in the smooth intestinal muscle. Key words: Syzygium cumini, antidiarrhoeal activity, antispasmodic effect, leaves, rat jejunum. |
| Databáze: | OpenAIRE |
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