Intermittent Fasting of High‐Fat Diet Increases Hypothalamic Norepinephrine and Improves Metabolic Parameters in Obese Mice
| Autor: | Bryn L. Yeomans, Jessica L. Verpeut, Troy A. Roepke, Juliet D. Gotthardt, Nicholas T. Bello |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
business.industry digestive oral and skin physiology nutritional and metabolic diseases food and beverages Male mice High fat diet Biochemistry Norepinephrine (medication) Endocrinology Weight loss Internal medicine Intermittent fasting Genetics Ketone bodies Medicine medicine.symptom business Molecular Biology Biotechnology medicine.drug Obese Mice Insulin tolerance |
| Zdroj: | The FASEB Journal. 29 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fasebj.29.1_supplement.lb231 |
| Popis: | Alternate day, intermittent fasting (IMF) can promote weight loss in obese individuals. We investigated the metabolic and neural mechanisms of IMF in diet-induced obese mice. Twenty-four C57 male mice at PND 49 were fed a high-fat diet (HFD; 45% fat, 20% protein, 35% CHO) ad libitum for 8 wks. Following this, for 4 wks, mice (n = 8/group) were maintained on ad libitum HFD, received IMF of HFD (IMF-HFD), or were switched to ad libitum low-fat diet (LFD;10% fat, 20% protein, 70% CHO). Body weight and cumulative calorie intake were not different between the IMF-HFD and LFD. Indeed, both groups had reduced cumulative caloric intake (~13% for both; p < 0.01) and reduced body weight (~10% for both; p < 0.05) compared with the HFD. Metabolic parameters, however, were different between the IMF-HFD and LFD groups. Insulin tolerance was improved in IMF-HFD compared with the HFD group (- 20% glucose AUC; p < 0.05), but impaired compared with LFD (+ 22% glucose AUC; p |
| Databáze: | OpenAIRE |
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