ChemInform Abstract: Bicyclic Imidazolidinones as Potential Antibiotics

Autor:	Léon Ghosez, Jacqueline Marchand-Brynaert, H. Vanlierde
Rok vydání:	1989
Předmět:	Serine Penicillin Carbamate Bicyclic molecule medicine.drug_class Stereochemistry Chemistry medicine.medical_treatment Antibiotics medicine General Medicine Antibacterial activity medicine.drug
Zdroj:	ChemInform. 20
ISSN:	0931-7597
DOI:	10.1002/chin.198924306
Popis:	The bicyclic imidazolidinones 5 topologically related to the penicillin family, are susceptible to form a stable carbamate with serine- D, D-peptidases. A series of N-7 acylated or sulfonylated (2R, 5R)- 3,3-dimethyl-8-oxo-4-thia-7, 1-diazabicyclo[3.3.0]octane-2-carboxylates 12–21 have been prepared. None of these novel penicillin analogs exhibited antibacterial activity.
Databáze:	OpenAIRE
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