Case-control study of statin prevention of mould infections
| Autor: | Jessica N. Thompson, Chris A. Gentry, Mark M. Huycke, Ronald A. Greenfield, George Kurdgelashvili |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Drug
medicine.medical_specialty Statin Index date medicine.drug_class business.industry media_common.quotation_subject Case-control study Dermatology General Medicine Statin treatment Pharmacology Transplantation Infectious Diseases Steroid use Internal medicine medicine business Veterans Affairs media_common |
| Zdroj: | Mycoses. 54:e481-e485 |
| ISSN: | 0933-7407 |
| DOI: | 10.1111/j.1439-0507.2010.01957.x |
| Popis: | Summary Invasive mould infections (IMI) are associated with significant morbidity and mortality. In vitro studies have demonstrated that hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have activity against several pathogenic moulds including Zygomycetes and Aspergillus spp. The aim of our study was to determine if statin use is a preventive factor for the development of IMI. This was a retrospective case–control study of 10 United States Veterans Affairs Medical Centers that comprise the Veterans Integrated Service Network (VISN) 16. Cases with IMI and controls were identified from 2001 to 2008. Controls were matched by age, facility, history of transplantation, presence of chronic steroid use and presence of human immunodeficiency virus infection (HIV). Two hundred and thirty-eight patients were included. Independent variables associated with the development of IMI were history of solid malignant tumours (OR 2.63, 1.41–4.87) and hypertension (OR 2.29, 1.13–4.68). Statin use within 3 months of index date was not an independent variable for prevention or development of IMI. No level of exposure to a statin drug appeared to influence the development of infection. This retrospective case–control study suggests that despite evidence of in vitro activity, statins may not decrease risk of IMI. Prospective, controlled trials may be necessary to investigate any potential clinical benefit. |
| Databáze: | OpenAIRE |
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