Ultrasound assisted multicomponent reactions: A green method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular reusable catalyst in water

Autor:	Kishor D. Mane, Charansingh H. Gill, Mukesh D. Nikam, Jagdish S. Kshirsagar, Pradip A. Gaikwad, Asha V. Chate, Umesh B. Rathod, Pravin S. Mahajan
Rok vydání:	2016
Předmět:	Tandem Aqueous medium 010405 organic chemistry education Supramolecular chemistry General Medicine 010402 general chemistry 01 natural sciences humanities 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Dimedone Yield (chemistry) Michael reaction Organic chemistry Selectivity
Zdroj:	Chinese Journal of Catalysis. 37:146-152
ISSN:	1872-2067
DOI:	10.1016/s1872-2067(15)61005-1
Popis:	We demonstrate a superficial method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular, biodegradable, and reusable catalyst in aqueous medium. The reaction product is in excellent yield with moderate to excellent selectivity. The mechanistic transformation presumably proceeds via a one-pot, multicomponent cyclization of dimedone in the presence of aromatic aldehydes and aromatic amines/INH, undergoing a tandem Michael addition reaction. The proposed approach in this study provides a highly efficient and environmentally benign route to N-substituted 1,8-dioxo-decahydroacridines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::27eba616f317e25479e66010f5aca260 https://doi.org/10.1016/s1872-2067(15)61005-1 Zobrazit plný text záznamu Full Text from ScienceDirect