Immunopharmacological studies of bucillamine in rheumatoid arthritis

Autor:	Takatoshi Kitano, Haruo Tsuji, Chisako Okada, Hiroaki Matsuno, Isao Matsushita
Rok vydání:	1992
Předmět:	CD20 biology business.industry T cell Bucillamine Arthritis medicine.disease Titer medicine.anatomical_structure Rheumatoid arthritis Immunology medicine biology.protein CD5 business CD8 medicine.drug
Zdroj:	Ensho. 12:251-256
ISSN:	1884-4006 0389-4290
DOI:	10.2492/jsir1981.12.251
Popis:	We investigated the immunological effects of bucil-lamine which has been known as an immunomodula-ting drug with no anti-inflammatory effects, in 80 rheumatoid arthritis (RA) patients by using the flowcytometric analysis. All patients treated with bucillamine have been followed up for 12 months or over. Long term administration of bucillamine markedly improved arthritis related to the decrease titer of RAHA. Moreover, T cell subsets in the peripheral blood showed that the cell constituent ratio of CD4+ CD45RA+, characteristically increased by administration of bucillamine. On the other hand, CD4+CD 45RO+, CD4+HLA-DR+, CD8+HLA-DR+ and CD 5+CD20+ significantly decreased in accordance with the activity of RA. These results suggested that bucillamine play a role of an alterative lymphocyte subsets and improving the severity of RA.
Databáze:	OpenAIRE
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