Comprehensive analysis of the clinicopathological features, targetable profile, and prognosis of mucinous adenocarcinoma of the lung

Autor: Ana Giménez-Capitán, Masaoki Ito, Ruth Román-Lladó, Koji Arihiro, Yukio Takeshima, Cristina Aguado, Miguel Angel Molina-Vila, Ana Pérez-Rosado, Rafael Rosell, Daisuke Ueda, Morihito Okada, Yoshihiro Miyata, Yasuhiro Tsutani, Kei Kushitani
Rok vydání: 2021
Předmět:
Zdroj: Journal of Cancer Research and Clinical Oncology. 147:3709-3718
ISSN: 1432-1335
0171-5216
DOI: 10.1007/s00432-021-03609-3
Popis: The clinicopathological or genetic features related to the prognosis of mucinous adenocarcinoma are unknown because of its rarity. The clinicopathological or targetable features were investigated for better management of patients with mucinous adenocarcinoma of the lung. We comprehensively evaluated the clinicopathological and genetic features of 60 completely resected mucinous lung adenocarcinomas. Targetable genetic variants were explored using nCounter and polymerase chain reaction, PD-L1 and TTF-1 expression were evaluated using immunohistochemistry. We analyzed the prognostic impact using the Kaplan–Meier method and log-rank test. Of the 60 enrolled patients, 13 (21.7%) had adenocarcinoma in situ/minimally invasive adenocarcinoma, and 47 (78.3%) had invasive mucinous adenocarcinoma (IMA). Fifteen patients (25%) showed a pneumonic appearance on computed tomography (CT). CD74-NRG1 fusion, EGFR mutations, and BRAF mutation were detected in three (5%), four (6.7%), and one (1.7%) patient(s), respectively. KRAS mutations were detected in 31 patients (51.7%). Two patients (3.5%) showed immunoreactivity for PD-L1. No in situ or minimally invasive cases recurred. IMA patients with pneumonic appearance had significantly worse recurrence-free survival (RFS) and overall survival (OS) (p
Databáze: OpenAIRE
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