SINGLE NUCLEOTIDE POLYMORPHISM –308 G/A OF TUMOR NECROSIS FACTOR-ALPHA (TNF) GENE IN TYPE 2 DIABETES MELLITUS PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASESE
| Autor: | V. V. Poltorak, Yu. I. Karachentsev, T. V. Tyzhnenko, Zh. A. Leshchenko, N. S. Krasova, A. I. Gladkih, A. A. Cherniaieva, O. O. Plohotnichenko, L. O. Atramentova, M. Y. Gorshunska, N. O. Kravchun, A. K. Pochernyayev, Y. A. Opaleiko, I. V. Chernyavskaya |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Candidate gene business.industry Endocrinology Diabetes and Metabolism Fatty liver Type 2 Diabetes Mellitus Single-nucleotide polymorphism Type 2 diabetes medicine.disease Pathology and Forensic Medicine Endocrinology Internal medicine Diabetes mellitus Nonalcoholic fatty liver disease medicine business Allele frequency |
| Zdroj: | Problems of Endocrine Pathology. 54:44-52 |
| ISSN: | 2518-1432 2227-4782 |
| DOI: | 10.21856/j-pep.2015.4.06 |
| Popis: | Single nucleotide polymorphism in the promoter region –308 G/A of tumor necrosis factoralpha gene (TNF) in type 2 diabetes mellitus patients (n = 118) and healthy habitants of Kharkiv (n = 50) was studied. There were no significant differences in allele frequencies for single nucleotide polymorphism –308 G/A in patients with type 2 diabetes (pG = 0.861, qA = 0.157), patients with type 2 diabetes in the presence of fatty liver disease (pG = 0.873, qA = 0.127) and healthy individuals (pG = 0.930, qA = 0.070). According to our data the contribution of genetic components in the predisposition to the formation of non-alcoholic fatty liver disease in individuals with diabetes on single nucleotide polymorphism –308 G/A TNF gene was not identified. The obtained data have proved promising for further research, which should be based on a study of the role other candidate genes in the development of nonalcoholic fatty liver disease and their relationship to various metabolic parameters, which will clarify the role of genes in the formation of disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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