Implementation of pharmacogenetics: The University of Maryland personalized anti-platelet pharmacogenetics program
| Autor: | Nicholas P. Ambulos, Richard Y. Zhao, Mark R. Vesely, Courtney O'Neill, Tameka D. Alestock, Miriam G. Blitzer, Patrick F. McArdle, Toni I. Pollin, Richard B. Horenstein, Ruth E. Pakyz, Lawrence Brown, Shaun Bhatty, Amber L. Beitelshees, Alan R. Shuldiner, Linda J. B. Jeng, Kathleen Palmer, Jamie Schub, Mark D. Kelemen, Shawn W. Robinson, Casey Lynnette Overby, Kristin A. Maloney |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Translational research Pharmacology Precision medicine Clinical decision support system Pharmacogenomics Genetics Platelet aggregation inhibitor Medicine Medical physics Personalized medicine business Genetics (clinical) Pharmacogenetics Genetic testing |
| Zdroj: | American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 166:76-84 |
| ISSN: | 1552-4868 |
| Popis: | Despite a substantial evidence base, implementation of pharmacogenetics into routine patient care has been slow due to a number of non-trivial practical barriers. We implemented a Personalized Anti-platelet Pharmacogenetics Program (PAP3) for cardiac catheterization patients at the University of Maryland Medical Center and the Baltimore Veterans Administration Medical Center Patients' are offered CYP2C19 genetic testing, which is performed in our Clinical Laboratory Improvement Amendment (CLIA)-certified Translational Genomics Laboratory. Results are returned within 5 hr along with clinical decision support that includes interpretation of results and prescribing recommendations for anti-platelet therapy based on the Clinical Pharmacogenetics Implementation Consortium guidelines. Now with a working template for PAP3, implementation of other drug-gene pairs is in process. Lessons learned as described in this article may prove useful to other medical centers as they implement pharmacogenetics into patient care, a critical step in the pathway to personalized and genomic medicine. © 2014 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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