New sesquiterpene glycoside ester with antiprotozoal activity from the flowers of Calendula officinalis L
| Autor: | Longxin Qiu, Ahmed A. Zaki, Ahmed Ashour |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
biology Traditional medicine 010405 organic chemistry Chemistry medicine.drug_class Organic Chemistry Leishmania donovani Glycoside Plant Science Trypanosoma brucei biology.organism_classification Sesquiterpene 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Calendula officinalis Antiprotozoal medicine Calendula Amastigote |
| Zdroj: | Natural Product Research. 35:5250-5254 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Continued chromatographic investigation of Calendula officinalis flowers led to the isolation of two sesquiterpenes, including one new, viridiflorol-10-O-β-quinovopyranoside-2`-O-(3``-methyl-2``-pentenoate) (1), along with a previously reported compound viridiflorol-10-O-β-fucopyranoside-2`-O-(3``-methyl-2``-pentenoate) (2). The new compound 1 was tested for antiprotozoal activity against Leishmania donovani Amastigote/THP1 and Trypanosoma brucei and it showed IC50 values of 3.57 and 7.84 µg/mL, respectively, while compound 2 exhibited no activity at the highest concentration tested 10 µg/mL. |
| Databáze: | OpenAIRE |
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