Relationship between histologic response and the degree of tumor shrinkage after chemoradiotherapy in patients with locally advanced rectal cancer
| Autor: | Toshiyuki Suzuki, Sotaro Sadahiro, Gota Saito, Shuichi Kawada, Akemi Kamijo, Kazutake Okada, Takeshi Akiba, Akira Tanaka |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Colorectal cancer medicine.medical_treatment Tumor shrinkage Magnetic resonance imaging General Medicine medicine.disease Tegafur Total mesorectal excision Radiation therapy Oncology medicine Surgery Radiology business Nuclear medicine Chemoradiotherapy medicine.drug Barium enema |
| Zdroj: | Journal of Surgical Oncology. 109:659-664 |
| ISSN: | 0022-4790 |
| Popis: | Background Preoperative chemoradiotherapy (CRT) significantly decreases local recurrence in advanced rectal cancer. We studied whether the degree of tumor shrinkage can be used as a predictor of histologic response. Methods The subjects were 114 patients with locally advanced rectal cancer who underwent total mesorectal excision after receiving radiotherapy combined with uracil/tegafur (UFT) or S-1. The degree of tumor shrinkage based on barium enema examination and magnetic resonance imaging (MRI) were assessed before CRT and immediately before surgery. Results A histologic complete response (ypCR), histologic marked regression, T and N downstaging were associated with significantly higher tumor-shrinkage rates on barium enema (P |
| Databáze: | OpenAIRE |
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