Acute autoimmune response in a case of 3yromellitic acid dianhydride-induced hemorrhagic alveolitis

Autor: Ruedi Speich, Vladimir Kaplan, Xaver Baur, A. B. Czuppon
Rok vydání: 1994
Předmět:
Zdroj: Allergy. 49:337-341
ISSN: 1398-9995
0105-4538
DOI: 10.1111/j.1398-9995.1994.tb02278.x
Popis: A 17-year-old man was occupationally exposed to pyromellitic acid dianhydride dust during the production of epoxy resin in a chemical factory. He was clinically diagnosed as having acute hemorrhagic alveolitis associated with anemia. The serologic analysis revealed a high concentration of IgG antibodies against pyromellitic acid dianhydride-treated human serum albumin (PMDA-HSA). Immunoblotting with PMDA-treated human serum as antigen and the patient's serum as the first antibody showed that additional PMDA-modified serum proteins other than HSA were recognized by the patient's IgG antibodies in the higher mol. mass range (> 67 kDa). No specific IgG could be detected against other anhydride conjugates (maleic acid, MA; phthalic acid, PA) with the exception of a reaction with the trimellitic acid anhydride-conjugated HSA (TMA-HSA). No specific IgE antibodies could be detected against any of the above mentioned antigens, but immunoblotting of the patient's serum indicated IgG4-type autoantibodies against in vitro PMDA-treated Ig molecules of normal serum proteins.
Databáze: OpenAIRE
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