Metal ion release from titanium with active oxygen species generated by rat macrophagesin vitro
| Autor: | Ying Mu, Takao Hanawa, Masae Sumita, T. Kobayashi, Akiko Yamamoto |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Materials science biology Metal ions in aqueous solution Biomedical Engineering chemistry.chemical_element Fretting Polyethylene Titanio biology.organism_classification Surgery Ion Biomaterials Metal chemistry.chemical_compound chemistry Chemical engineering visual_art visual_art.visual_art_medium medicine High-density polyethylene Titanium |
| Zdroj: | Journal of Biomedical Materials Research. 49:238-243 |
| ISSN: | 1097-4636 0021-9304 |
| Popis: | The release of metal ions due to active oxygen species generated by macrophages (Mphi) phagocytosing high-density polyethylene (HDPE) particles was studied in vitro to investigate the mechanism behind the release of metal ions from titanium implants into nearby tissues in the absence of wear and fretting in vivo. To determine the effects of Mphis on metal ion release, titanium disks were immersed in different solutions and the titanium ions released from the titanium disks into each solution were quantified. The results revealed that active oxygen species generated by Mphis induced the metal ion release. In particular, the ion release was accelerated with HDPE because the Mphis that phagocytosed HDPE generated more active oxygen species than Mphis that did not phagocytose any HDPE. Metal ions were also released by organic species in the absence of Mphis. These are some of the causes for metal ion release from titanium implants in the absence of wear and fretting in vivo. |
| Databáze: | OpenAIRE |
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