H2SO4-Mediated Intramolecular Cyclization of N-Arylated Homoallylamines: A Solvent-Free, Atom- and Step-Economical Synthesis of Tetrahydro-1-benzazepines

Autor:	Fei Dou, Rui Sun, Li-Ming Zhao, Hua-Shuai Gao, Ai-Li Zhang
Rok vydání:	2016
Předmět:	Reaction conditions Benzazepines Solvent free 010405 organic chemistry Chemistry Organic Chemistry Intramolecular cyclization 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Solvent Atom Organic chemistry
Zdroj:	Synthesis. 49:1597-1602
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0036-1588375
Popis:	The biologically important tetrahydro-1-benzazepine skeleton was conveniently constructed from N-arylated homoallylamines through H2SO4-mediated intramolecular cyclization. The advantages of this transformation include mild reaction conditions, experimental simplicity, its solvent- and metal-free, atom- and step-economical nature, and the use of a readily available, cheap, and nontoxic mediator.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::27b0521dd1514bd224ed447d9b3354da https://doi.org/10.1055/s-0036-1588375 Zobrazit plný text záznamu