A Palladium-Catalysed Urea Arylation Route to a CRF1 Receptor Antagonist

Autor:	Richard K. Bellingham, Jerome F. Hayes, Matthew E. Popkin
Rok vydání:	2006
Předmět:	Organic Chemistry Crf1 receptor Antagonist chemistry.chemical_element Ring (chemistry) Medicinal chemistry Catalysis Piperazine chemistry.chemical_compound chemistry Intramolecular force Urea Organic chemistry Palladium
Zdroj:	Synlett. 2006:2716-2718
ISSN:	1437-2096 0936-5214
Popis:	A new synthetic approach to a potent CRF antagonist, GW808990 (NBI35583), is reported. The route hinges on the palladium-catalysed intramolecular arylation of a urea with 2-chloropyridine. Spontaneous piperazine ring closure means that a high-yielding bisannulation reaction is the final step.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::27aebe96ac32f38c2318bf28be3fb5fc https://doi.org/10.1055/s-2006-950276 Zobrazit plný text záznamu