| Autor: |
Sümeyya Deniz AYBEK, Ömer ATEŞ, Saime SEZER SONDAŞ, Ali GÜL, Şahin TAKÇI, Buket ALTINTAŞ SEYYAH |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cukurova Medical Journal. 47:1440-1446 |
| ISSN: |
2602-3032 |
| Popis: |
Purpose: The aim of this study was to investigate whether there is a relationship between surfactant protein B (SFTPB) C1580T polymorphism and acute bronchiolitis. Materials and Methods: The study analyzed the allele frequency and genotype distribution for the SFTPB C1580T polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in 103 acute bronchiolitis infants and 102 healthy infants. Results: The results showed no association between SFTPB C1580T polymorphism and clinical characteristics of acute bronchiolitis. The distribution of the CT genotype was higher in acute bronchiolitis infants (43%) than in healthy subjects (39%) and distribution of the TT genotype was found lower in acute bronchiolitis infants (38%) than in healthy subjects (41%). No significant differences in genotype distribution and allele frequency for the SFTPB C1580T polymorphism were found between case group and control group Conclusion: SFTPB C1580T gene polymorphism plays no important role in susceptibility to acute bronchiolitis. Further work on the relevance of SFTPB C1580T polymorphism in larger cohorts will require validating our results. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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