Studies of Saturated Heterocyclic Compounds. II. The Preparation and PMR Spectroscopic Study of Mono- and Di-substituted-1,3-dioxolan-4-ones

Autor:	Yojiro Tsuzuki, Shoji Takitani, Yoshihiro Asabe
Rok vydání:	1975
Předmět:	Coupling constant Chemistry Stereochemistry General Chemistry Spectroscopy Medicinal chemistry Cis–trans isomerism
Zdroj:	Bulletin of the Chemical Society of Japan. 48:966-970
ISSN:	1348-0634 0009-2673
DOI:	10.1246/bcsj.48.966
Popis:	The relationship of the configurations and the magnitude of the long-range spin coupling constants between the 2-H and 5-H, J2,5, of 1,3-dioxolan-4-ones has been elucidated, the J2,5(trans) value being always larger than the J2,5(cis) value. Geometrical isomers of several 2,5-disubstituted derivatives have been separated by means of preparative tlc and assigned by means of PMR spectroscopy, especially by the use of their J2,5 values. The sign of the J2,5, values for a 2-trichloromethyl derivative has been determined by a partial decoupling experiment, both J2,5(cis) and J2,5, (trans) being positive.
Databáze:	OpenAIRE
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