Demonstration of the Broad-Spectrum In Vitro Activity of Finafloxacin against Pathogens of Biodefense Interest
| Autor: | Sarah V. Harding, Stephanie A. Halasohoris, Purvi D. Desai, Steven D. Zumbrun, Lynda L. Miller, Mark I. Richards, P. Russell, Christine Bentley, Kay B. Barnes |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
0303 health sciences 030306 microbiology medicine.drug_class Chemistry Antimicrobial efficacy Antibiotics Broth microdilution In vitro Microbiology 03 medical and health sciences Broad spectrum Finafloxacin chemistry.chemical_compound Infectious Diseases In vivo medicine Pharmacology (medical) 030304 developmental biology |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 63 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | This study investigated the in vitro activity of finafloxacin against panels of the biodefence pathogens. Broth microdilution assays were performed at neutral and acidic pH, to determine the effectiveness of the antibiotics in conditions typical of an intracellular environment. In all instances, finafloxacin demonstrated superior activity at low pH. These results highlight the importance of evaluating antimicrobial efficacy in conditions relevant to those encountered in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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