Molecular Surgery for the Treatment of Malignant Tumors: Bioincompatible Material Apheresis for Cancer Therapy?
| Autor: | Kuniaki Natsume, Yukihiko Nosé, Kazuhide Ohta, Junji Takaba, Hiroshi Miyamoto |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Lung business.industry Biomedical Engineering Cancer therapy Medicine (miscellaneous) Cancer Bioengineering Endotracheal intubation General Medicine medicine.disease Surgery Biomaterials medicine.anatomical_structure Apheresis Apoptosis Shock (circulatory) medicine Tumor necrosis factor alpha medicine.symptom business |
| Zdroj: | Artificial Organs. 35:308-315 |
| ISSN: | 0160-564X |
| DOI: | 10.1111/j.1525-1594.2010.01196.x |
| Popis: | Controlled immunological shock, induced by bioincompatible material apheresis for cancer (BIC MAC) therapy, produces an immunoactive status in experimental subjects. However, in order to provide a safe, painless, effective, and reproducible BIC MAC therapy, it is mandatory to provide general anesthesia with endotracheal intubation not only during apheresis procedures of 1-h duration but also for an additional 5 h. Using this procedure, there was no mortality experienced during animal experiments. Also, there were no procedurally related physical or sensory abnormalities demonstrated. This general anesthesia of 6 h covered not only the initial 30 min of the hypotension and hypoxic stages but also the recovery stages to hemodynamically normalize the experimental animals. After 6 h, the accumulated leukocytes in the lung are released back to the systemic circulation. In general, granulocytes decreased almost 100% while lymphocytes decreased only 40-50%. During these 6 h, increases of cytokines (tumor necrosis factor-α, interleukin-6, etc.) sometimes up to 1000 times occurred. After the 6-h procedure, leukocytes returned nearly to preoperative levels but tended to be continuously increased. After the fourth day, leukocyte counts more than doubled. These cellular and humoral activations were normalized after 2 weeks. These studies were conducted on six normal mongrel dogs. Currently, similar studies are planned to be conducted on tumor-bearing experimental animals. This procedurally induced immunoactivation by apheresis may be able to produce effective apoptosis in malignant tumor cells. |
| Databáze: | OpenAIRE |
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