Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage
| Autor: | Jin Park, Kyung Oh Doh, Philip J. Bilan, Kyoung-Han Kim, Amira Klip, Samer M.I. Hussein, Jeong Ah Yoo, Florine Lenglin, Min Seon Choe, Yun Hye Kim, Sarah Kim, Ju Hee Lee, Chi-chung Hui, Hoon Ki Sung, Kiya Fu, Jian Zhong, Andras Nagy, Joon Ho Moon, Jae Ryong Kim, Joe Eun Son |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
2. Zero hunger medicine.medical_specialty Adipose tissue Cell Biology White adipose tissue Biology Vascular endothelial growth factor Transcriptome 03 medical and health sciences chemistry.chemical_compound Vascular endothelial growth factor A 030104 developmental biology Endocrinology chemistry Internal medicine Intermittent fasting medicine Molecular Biology Thermogenesis Homeostasis |
| Zdroj: | Cell Research. 27:1309-1326 |
| ISSN: | 1748-7838 1001-0602 |
| Popis: | Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. IF-induced metabolic benefits require fasting-mediated increases of vascular endothelial growth factor (VEGF) expression in white adipose tissue (WAT). Furthermore, periodic adipose-VEGF overexpression could recapitulate the metabolic improvement of IF in non-fasted animals. Importantly, fasting and adipose-VEGF induce alternative activation of adipose macrophage, which is critical for thermogenesis. Human adipose gene analysis further revealed a positive correlation of adipose VEGF-M2 macrophage-WAT browning axis. The present study uncovers the molecular mechanism of IF-mediated metabolic benefit and suggests that isocaloric IF can be a preventive and therapeutic approach against obesity and metabolic disorders. |
| Databáze: | OpenAIRE |
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