Coordination metal complexes with Schiff bases: Useful pharmacophores with comprehensive biological applications
| Autor: | Kavita Poonia, Anita Choudhary, Dinesh Kumar, Priyanka Ghanghas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Antifungal
medicine.drug_class Dna interaction Population 02 engineering and technology 010402 general chemistry 01 natural sciences Coordination complex Inorganic Chemistry Metal chemistry.chemical_compound Materials Chemistry medicine Physical and Theoretical Chemistry education chemistry.chemical_classification education.field_of_study Schiff base Chemistry 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences visual_art visual_art.visual_art_medium Pharmacophore 0210 nano-technology |
| Zdroj: | Inorganic Chemistry Communications. 130:108710 |
| ISSN: | 1387-7003 |
| DOI: | 10.1016/j.inoche.2021.108710 |
| Popis: | Antibiotic-resistant infections on the health care system and the population have put a burden on economic and adequate health. There is an urgent need to develop new synthetic moieties with a better and acceptable therapeutic index. Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds. Schiff bases metal complexes are proven as potential candidates who show effective activity towards anti-inflammatory, antifungal, antibacterial, antiproliferative, antimalarial, antipyretic, antiviral properties etc. The occurrence of basic donor N, S and O atoms in the skeleton of the Schiff base makes them well-suited ligands in coordinating chemistry. They are found to be a versatile pharmacophore for designing and developing many bioactive lead compounds. This review begins with a brief introduction to Schiff bases and their complexes. It summarizes the various biological activities (antimicrobial activities, antioxidant activities, DNA interactions, anticancer activities) delivered by Schiff base metal complexes. It also highlights the recent advancement in the field of Schiff base coordination chemistry and its future prospects as a potential bioactive core. |
| Databáze: | OpenAIRE |
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