Autor: Héctor Pons, Nereida Valero, Ernesto Bonilla, Florencio Añez, Leonor Chacín-Bonilla, Beatriz Negrette, Shirley Medina-Leendertz, Jorge García Tamayo
Rok vydání: 2001
Předmět:
Zdroj: Neurochemical Research. 26:767-770
ISSN: 0364-3190
Popis: To determine whether treatment with melatonin (MLT) improves the efficiency of immunization against Venezuelan equine encephalomyelitis (VEE) virus, mice were vaccinated with TC-83 VEE virus and treated daily with MLT (1 or 5 mg/kg) starting 3 days before immunization, until 10 days after. IgM antibody titers were determined at days 7, 14, and 21 post-immunization. IL-10 levels were assayed at day 14 postvaccination. Treatment with MLT increased antibody titers 14 days after the immunization. IL-10 levels also increased with MLT treatment (1 and 5 mg/kg). Mice were challenged with live VEE virus at day 21 postimmunization, and viral titers were plaque assayed in chicken embryo fibroblasts 4 days after the infection. Following this challenge brain virus levels were significantly reduced. The results suggest that MLT treatment enhances the efficiency of mice immunization against VEE virus.
Databáze: OpenAIRE
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