Levels of Vitellogenin in Male Japanese Medaka (Oryzias latipes) Exposed to the Chemotherapeutics: Oxytetracycline, Romet-30®, and Copper Sulfate

Autor:	Gregory D. Boardman, Kimberly E. Tulou, George J. Flick, Stephen A. Smith
Rok vydání:	2008
Předmět:	medicine.medical_specialty Ecology biology Oryzias Copper sulfate Japanese Medaka Estrogenic Compounds Oxytetracycline Aquatic Science biology.organism_classification Body weight Vitellogenin Endocrinology Animal science Internal medicine biology.protein medicine Fish medicine.drug
Zdroj:	Journal of Applied Aquaculture. 20:149-167
ISSN:	1545-0805 1045-4438
DOI:	10.1080/10454430802329614
Popis:	Japanese medaka (Oryzias latipes) were exposed to oxytetracycline and Romet-30® at daily doses via feed of 0.06 mg, 0.11 mg, and 0.28 mg per gram body weight for 11 days, and at daily doses of 0.05 mg, 0.10 mg, and 0.15 mg per gram body weight for 5 days, respectively. In addition, fish were exposed to copper sulfate in their aquaria water at 1.85 mg/L for 1 h each day (over a span of 1 day, 7 consecutive days, or 1 day in every 3 to 5 days for a total of seven doses). Vitellogenin levels were measured in fish using a sandwich enzyme-linked immunosorbent assay (ELISA). Vitellogenin levels were not induced from exposure to either oxytetracycline or Romet-30® (P > 0.05); however, copper sulfate for 1 h on 1 day showed a decrease in vitellogenin from the control fish and other treatment groups (P = 0.007). Under these test conditions, oxytetracycline, Romet-30, and copper sulfate were not found to act in medaka as estrogenic compounds by inducing vitellogenin.
Databáze:	OpenAIRE
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