RAFT-based synthesis and the gelation property of telechelic polymers that can immobilize biomacromolecules
| Autor: | Keita Kinoshita, Yuta Mori, Yoshihiko Murakami, Taku Takami, Yusuke Uchida |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Acrylate Polymers and Plastics Organic Chemistry Chain transfer 02 engineering and technology Polymer Raft 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Self-healing hydrogels Polymer chemistry Materials Chemistry Reversible addition−fragmentation chain-transfer polymerization 0210 nano-technology Surface protein Macromolecule |
| Zdroj: | Journal of Polymer Science Part A: Polymer Chemistry. 55:1356-1365 |
| ISSN: | 0887-624X |
| DOI: | 10.1002/pola.28504 |
| Popis: | Telechelic polymers, macromolecules having two reactive end groups, can serve as building blocks for constructing polymers or polymeric materials that have complex architectures. Among the telechelic polymers, polymers bearing hydroxyl groups at two terminals have been used as components for preparation of functional materials. In the present study, RAFT polymerization of both N-acryloylmorphorin and N-succinimidyl acrylate by using a newly synthesized dithiobenzoate-type chain transfer agent bearing hydroxyl groups at both terminals (HECPHD) was reported. After the acryloylation of the hydroxyl terminals of the obtained polymer, gelation was observed. Furthermore, the polymer could react with a protein via the conjugation of the succinimidyl esters-containing polymers to the amino groups present on the protein surface. The results show that activated esters-bearing polymers with hydroxyl groups at both terminals can be used as building blocks for constructing polymeric materials for an immobilization of biomacromolecules. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1356–1365 |
| Databáze: | OpenAIRE |
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