RNA editing intermediates of cox2 transcripts in maize mitochondria

Autor:	R M Mulligan, Austin J. Yang
Rok vydání:	1991
Předmět:	Genetics Exon RNA editing Sequence analysis RNA splicing Nucleic acid sequence RNA Coding region Cell Biology Biology Molecular Biology Peptide sequence Cell biology
Zdroj:	Molecular and Cellular Biology. 11:4278-4281
ISSN:	1098-5549 0270-7306
DOI:	10.1128/mcb.11.8.4278
Popis:	Eighteen cytidines are changed to uridines in the coding sequence of transcripts for cytochrome c oxidase subunit 2 (cox2) in maize mitochondria. The temporal relationship of editing and splicing was examined in cox2 transcripts by sequence analysis of spliced and unspliced cDNAs. Cloned cDNAs of unspliced cox2 transcripts ranged from clones with no edited nucleotides to completely edited forms, while spliced cDNAs were nearly completely edited. Incompletely edited transcripts in the nascent pool of unspliced transcripts represent intermediates of the editing process. These results indicate that editing proceeds without a strong directional bias and suggest that RNA editing is a posttranscriptional process.
Databáze:	OpenAIRE
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