Memory outcome after temporal lobe epilepsy surgery: corticoamygdalohippocampectomy versus selective amygdalohippocampectomy

Autor:	Taner Tanriverdi, Roy William Roland Dudley, Alya Hasan, Ahmed Al Jishi, Qasim Al Hinai, Nicole Poulin, null M.Ed., Sophie Colnat-Coulbois, André Olivier
Rok vydání:	2010
Předmět:	Hippocampal sclerosis medicine.medical_specialty medicine.diagnostic_test Intelligence quotient business.industry General Medicine Neuropsychological test Neurological disorder medicine.disease Engel classification Temporal lobe Surgery Epilepsy Medicine Epilepsy surgery business Psychiatry
Zdroj:	Journal of Neurosurgery. 113:1164-1175
ISSN:	1933-0693 0022-3085
DOI:	10.3171/2009.10.jns09677
Popis:	Object The aim of this study was to compare IQ and memory outcomes at the 1-year follow-up in patients with medically refractory mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis. All patients were treated using a corticoamygdalohippocampectomy (CAH) or a selective amygdalohippocampectomy (SelAH). Methods The data of 256 patients who underwent surgery for MTLE were retrospectively evaluated. One hundred twenty-three patients underwent a CAH (63 [right side] and 60 [left side]), and 133 underwent an SelAH (61 [right side] and 72 [left side]). A comprehensive neuropsychological test battery was assessed before and 1 year after surgery, and the results were compared between the surgical procedures. Furthermore, seizure outcome was compared using the Engel classification scheme. Results At 1-year follow-up, there was no statistically significant difference between the surgical approaches with respect to seizure outcome. Overall, IQ scores showed improvement, but verbal IQ decreased after left SelAH. Verbal memory impairment was seen after left-sided resections especially in cases of SelAH, and nonverbal memory decreased after right-sided resection, especially for CAH. Left-sided resections produced some improvement in nonverbal memory. Older age at surgery, longer duration of seizures, greater seizure frequency before surgery, and poor seizure control after surgery were associated with poorer memory. Conclusions Both CAH and SelAH can lead to several cognitive impairments depending on the side of the surgery. The authors suggest that the optimal type of surgical approach should be decided on a case-by-case basis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2746809ff956dc6a304ea5a74b8bd10b https://doi.org/10.3171/2009.10.jns09677 Zobrazit plný text záznamu