Pirenzepine versus Cimetidine in Duodenal Ulcer Treatment

Autor:	R. W. Stockbruugger, P. Hoffmann, Hellner L, Dotevall G, J. Cronstedt, M. Hradsky, Jaup Bh, S. Seeberg
Rok vydání:	1985
Předmět:	medicine.medical_specialty Chemotherapy Smoking habit business.industry medicine.medical_treatment Gastroenterology Pirenzepine Duodenal ulcer Laboratory test medicine.anatomical_structure Internal medicine Dietary Nitrate Duodenum medicine Cimetidine business medicine.drug
Zdroj:	Scandinavian Journal of Gastroenterology. 20:183-188
ISSN:	1502-7708 0036-5521
DOI:	10.3109/00365528509089654
Popis:	The therapeutic efficacy of pirenzepine (PIR) and cimetidine (CIM) in duodenal ulcer and their effects on the intragastric milieu have been studied in a double-blind multicentre trial. Seventy-nine patients with endoscopically proven duodenal ulcer were randomly allocated to 4 weeks' treatment with either 50 mg PIR twice daily or 400 mg CIM twice daily. In addition to clinical and endoscopic evaluation and registration of side effects and laboratory test results, endoscopically obtained gastric juice was cultured and its nitrite concentration was measured before and at the end of the treatment. Seventy-five patients completed the study. The treatment groups were comparable with regard to age, sex, smoking habits, and consumption of coffee and alcohol. After 4 weeks, 27 of 37 patients (73%) in the PIR group were completely healed, compared with 29 of 38 (76%) in the CIM group (NS). The number of patients with side effects was similar in both groups, but side effects of antimuscarinic type were more frequen...
Databáze:	OpenAIRE
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