Acyclovir for the Prevention of Recurrent Herpes Simplex Virus Eye Disease

Autor:	Elisabeth J. Cohen, R. Doyle Stulting, Kirk R. Wilhelmus, Daniel B. Jones, Bruce Barron, Herbert E. Kaufman, Natalie Kurinij, Chandler R. Dawson, Pamela S. Moke, Roy W. Beck, Robert A. Hyndiuk, Joel Sugar, Penny A. Asbell
Rok vydání:	1998
Předmět:	medicine.medical_specialty business.industry viruses Eye disease General Medicine HSL and HSV Disease medicine.disease Placebo medicine.disease_cause Dermatology Virus Surgery Herpes simplex virus Recurrent herpes simplex medicine Sex organ business
Zdroj:	New England Journal of Medicine. 339:300-306
ISSN:	1533-4406 0028-4793
Popis:	Background Long-term treatment with antiviral agents has been shown to prevent recurrences of genital and orofacial herpes simplex virus (HSV) disease, but it is uncertain whether prophylactic treatment can prevent recurrences of ocular HSV disease. Methods We randomly assigned 703 immunocompetent patients who had had ocular HSV disease within the preceding year to receive 400 mg of acyclovir or placebo orally twice daily. The study outcomes were the rates of development of ocular or nonocular HSV disease during a 12-month treatment period and a 6-month observation period. Results The cumulative probability of a recurrence of any type of ocular HSV disease during the 12-month treatment period was 19 percent in the acyclovir group and 32 percent in the placebo group (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::273cd35b42653f26f7db9db21016ba6f https://doi.org/10.1056/nejm199807303390503 Zobrazit plný text záznamu