Huayu Pill (化瘀丸) Promotes Fluorescent Doxorubicin Delivery to Tumors in Mouse Model of Lung Cancer
| Autor: | Ke-Xin Cao, Lei Gao, Gan-Lin Zhang, Cai-Xia Hao, Xue-Man Ma, Guo-Wang Yang, Mingwei Yu, Xiaomin Wang, Qi-Wei Li |
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| Rok vydání: | 2020 |
| Předmět: |
Chemotherapy
business.industry medicine.medical_treatment 0211 other engineering and technologies 02 engineering and technology General Medicine Blood flow medicine.disease 030226 pharmacology & pharmacy In vitro Metastasis 03 medical and health sciences Regimen 0302 clinical medicine Complementary and alternative medicine 021105 building & construction Drug delivery Cancer research medicine Pharmacology (medical) Doxorubicin business Lung cancer medicine.drug |
| Zdroj: | Chinese Journal of Integrative Medicine. 27:514-519 |
| ISSN: | 1993-0402 1672-0415 |
| DOI: | 10.1007/s11655-020-3191-7 |
| Popis: | Objective: To study the effect and mechanism of Huayu Wan (化瘀丸, HYW) in combination of chemotherapy of tumor treatment. Methods: HYW serum was added in Lewis cells to assess its impact on fluorescent doxorubicin delivery in vitro. Then, Lewis tumor cells was implanted in C57BL/6 mice via xenograft transplantation. Tumor growth was measured and signal intensity corresponding to blood flow was assessed by laser doppler perfusion imaging (LDPI). Finally, the effect of HYW on the effificacy of doxorubicin was studied. Results: HYW can improve the transfer of fluorescent doxorubicin into cells. The blood flow signal in the tumor tissues of the HYW group was higher than that of the control group (P |
| Databáze: | OpenAIRE |
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