TEK BEYİN METASTAZLI HASTALARDA TÜM BEYİN VE SİMÜLTANE ENTEGRE BOOST RADYOTERAPİSİ / WHOLE BRAIN RADIOTHERAPY (WBRT) WITH SIMULTANEOUS INTEGRATED BOOST (SIB) IN PATIENTS WITH SINGLE BRAIN METASTASIS
| Autor: | Alaattin Özen, Melek Akçay, Suzan Şanlısoy, Evrim Metcalfe, Durmuş Etiz |
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| Rok vydání: | 2016 |
| Předmět: |
Simultaneous integrated boost
business.industry medicine.medical_treatment Hasta Treatment results medicine.disease 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine In patient Early phase Nuclear medicine business Lung cancer Brain metastasis |
| Zdroj: | OSMANGAZİ JOURNAL OF MEDICINE. 38 |
| ISSN: | 1305-4953 |
| Popis: | OZET: Bu calismanin amaci tek beyin metastazina sahip kucuk hucreli disi akciger kanseri (KHDAK) tanili hastalarda yogunluk ayarli radyoterapi (YART) planlama yontemi ile tum beyin radyoterapisi + simultane entegre boost (TBRT + SEB) teknigini kullanarak hedef dokuda doz yukseltilmesinin erken donem sonuclarinin degerlendirmesidir. Tek beyin metastazina sahip ve TBRT + SEB tedavisi uygulanan KHDAK tanili hastalar geriye donuk olarak degerlendirildi. Temmuz 2015 - Ocak 2016 arasinda toplamda 11 hastaya ulasildi. Hasta ve tumore ait ozellikler, demografik veriler, tedavi bilgisi ve ozellikleri incelendi. Tedavi suresince tum hastalara antiodem tedavi rutin baslandi. Hastalarda grade III-IV toksisite gozlemlenmedi. Hastalarin radyoterapiden 1 ay sonra cekilen beyin MR goruntuleri degerlendirildi ve tedavi oncesi beyin MR goruntuleri ile karsilastirilarak 7 (%63) hastada tam yanit, 4 (%37) hastada ise kismi yanit elde tespit edildi. Sonuc olarak TBRT + SEB teknigi radyocerrahi uygulamasina gore teknik olarak daha basit uygulanabilir, oldukca etkin ve hastalar tarafindan tolere edilebilir bir yontemdir. ANAHTAR KELIMELER: tum beyin radyoterapisi (TBRT), simultane entegre boost (SEB), akciger kanseri, tek beyin metastazi WHOLE BRAIN RADIOTHERAPY (WBRT) WITH SIMULTANEOUS INTEGRATED BOOST (SIB) IN PATIENTS WITH SINGLE BRAIN METASTASIS ABSTRACT: The aim of this study is to evaluate the early phase treatment results of dose escalation using by whole brain radiotherapy (WBRT) with simultaneous integrated boost (SIB) in non-small cell lung cancer patients with single brain metastasis. We evaluated retrospectively non-small cell lung cancer patients treated with WBRT + SIB. We achieved the data of 11 non-small cell lung cancer patients who were treated between July 2015 and January 2016. Patient and tumor characteristics, demographic data and treatment features have been evaluated. We prescribed antiedema treatment to all patients in whole duration of radiotherapy. We did not observe any grade III-IV toxicity. Cranial MRI images in the first month after radiotherapy has been evaluated and compared with preradiotherapy images. Complete response was identified in 7 (63%) patients and partial response was identified in 4 (37%) patients. In conclusion, WBRT + SIB technique is easier to apply when compared with radiosurgery, an effective and tolerable method for patients. KEYWORDS: Whole brain radiotherapy (WBRT), simultaneous integrated boost (SIB), lung cancer, single brain metastasis |
| Databáze: | OpenAIRE |
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