Improved Halogenation of Methyl Aromatics and Methyl Heteroaromatics: Unexpected Reactivity of Tetrahalogeno-diphenylglycolurils

Autor:	Florian Moretti, Guillaume Poisson, Alain Marsura
Rok vydání:	2016
Předmět:	Radical substitution 010405 organic chemistry Chemistry Reagent Halogen Halogenation Organic chemistry Reactivity (chemistry) General Chemistry 010402 general chemistry Selectivity 01 natural sciences 0104 chemical sciences
Zdroj:	Heteroatom Chemistry. 27:173-183
ISSN:	1042-7163
DOI:	10.1002/hc.21314
Popis:	1,3,4,6-Tetrachloro (TCDGU) and 1,3,4,6-tetrabromo-3α,6α-diphenylglycolurils smooth halogen oxidizers have been exploited in a new direction as reagents for free radical substitution toward some N-halosuccinimide nonreactive bis-heterocycles. An unexpected selectivity and reactivity were observed with methyl benzenes, methyl heterocycles, and methyl-bis-heterocycles of interest. A chemometric study has been performed to optimize five independent factors of the chlorination reaction with TCDGU. The predictive model was established either for the halogenation conversion and the ratio of monochlorination.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::27261c3d999cf1e8450743cfcbf33676 https://doi.org/10.1002/hc.21314 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.