The Effect of Two Different Routes of Administration of Oxytocin on Peripheral Plasma Prostaglandin F2α Metabolite Levels in Early Post-partum Dairy Cows
| Autor: | Árpád Csaba Bajcsy, J Bartyik, G.C. van der Weijden, Hans Kindahl, M.A.M. Taverne, Ottó Szenci |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Metabolite Uterus Prostaglandin Uterotonic Biology Contractility chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Oxytocin Internal medicine medicine Endocrine system Animal Science and Zoology Saline Biotechnology medicine.drug |
| Zdroj: | Reproduction in Domestic Animals. 47:208-212 |
| ISSN: | 0936-6768 |
| Popis: | Various parenteral treatment forms of oxytocin, as often used under praxis circumstances, may act differently on contractility of the uterus during the first days of the puerperium. Various patterns of such induced uterotonic responses may lead to alterations in the emptying characteristics of the uterine lumen, thus influencing, as a late consequence, the process of involution. Therefore, this study was designed to test whether two different parenteral administration forms of oxytocin induce changes in peripheral plasma concentrations of 15-ketodihydro-prostaglandin F(2α) (PGF(2α) metabolite) in early post-partum cows. Between 13 and 15 h after uncomplicated calving, healthy dairy cows without retained foetal membranes were treated with 50 IU oxytocin, either intramuscularly (OT-IM group; n = 15) or intravenously (OT-IV group; n = 16). Saline solution was administered intramuscularly as controls (CON group; n = 15). Jugular blood samples were taken at 10-min intervals from 1 h before to 2 h after treatment. Plasma PGF(2α) metabolite levels were measured by radioimmunoassay. No significant differences in peripheral plasma PGF(2α) metabolite concentrations occurred in the OT-IM and CON groups, but mean values significantly increased in the OT-IV group, peaking at 20 min after treatment and reaching pre-treatment baseline values again at 120 min. Although the source of prostaglandins was not investigated in this study, our results suggest that exogenous oxytocin may enhance secretion of prostaglandins by the uterus during the first day after normal calving. These prostaglandins might contribute, by an endocrine or paracrine route, to the stimulation of myometrial contractility when exogenous oxytocin is given during this early post-partum stage. |
| Databáze: | OpenAIRE |
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