Effect of hemodynamic characteristic changes of the carotid artery on 6-OHDA-induced Parkinson’s disease model rats treated by Gut-acupuncture
| Autor: | Jun Lu, Jing Wang, Li-hong Li, Xiao-qing Jin, Zhen-yu Shu, Hui-qian Liu, Li-song Zhu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Multidisciplinary Parkinson's disease Low oxygen business.industry Carotid arteries Hemodynamics 02 engineering and technology 010501 environmental sciences 021001 nanoscience & nanotechnology medicine.disease 01 natural sciences Neural stem cell Vagus nerve Lesion Internal medicine Acupuncture Cardiology Medicine medicine.symptom 0210 nano-technology business 0105 earth and related environmental sciences |
| Zdroj: | Journal of King Saud University - Science. 32:2675-2681 |
| ISSN: | 1018-3647 |
| DOI: | 10.1016/j.jksus.2020.03.038 |
| Popis: | Background Based on “gut-brain axis” theory, we employed a rat 6-OHDA lesion model to examine the impact of gut-acupuncture on motor symptoms, the abundance of DA neurons in the SN, the hemodynamic characteristics of the carotid artery and SNH. Methods 6-OHDA-induced PD rats were treated with gut-acupuncture daily, starting day 15 after surgery. Mobility of the limbs was evaluated, abundance of TH + DA neurons in the SN detected, The diameter of carotid arteries and hemodynamic parameters measured by cervical vascular ultrasound CVUS, and TCS utilized to examine SNH. Results Our data show that gut-acupuncture correlates with significantly increased abundance of TH, a marker of DA neurons compared to untreated rats. Furthermore the area of SNH in the injured side of the acupuncture group was significantly reduced. PSV of LCCA, LICA, RICA showed that were significantly improved i.e. decreased in the acupuncture group, while the diameter of LICA and RCCA in acupuncture group was narrower. We also found that the PSV was significantly increased and the vascular diameter narrowed in LCCA and LICA during treatment, whereas after removing the acupuncture needle the PSV decreased and the vascular diameter widened. Conclusions Gut-acupuncture can reduce SNH and influence TH abundance in the SN which correlated with changes of hemodynamic characteristics of the lesioned side. We suggest a regulatory mechanism which may affect the vagus nerve through the ENS and cause the change of cervical hemodynamics. It further induces low oxygen tension microenvironment conducive to the proliferation of neural stem cells, which leads to the enrichment of TH in PD model rats of acupuncture group. |
| Databáze: | OpenAIRE |
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