Wirkung von Nitroglycerinpflastern auf Hämodynamik und Belastbarkeit von Patienten mit koronarer Herzkrankheit

Autor:	P. Simon, W. Jansen, Th. Ulbrich, Tauchert M, A. Osterspey, H. H. Hilger
Rok vydání:	2008
Předmět:	medicine.medical_specialty Percutaneous business.industry Working capacity Hemodynamics General Medicine Pulmonary arterial pressure Coronary heart disease Blood pressure Internal medicine Anesthesia medicine Cardiology Cardiac frequency business Nitroglycerin medicine.drug
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 109:714-717
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1069260
Popis:	The haemodynamic and antianginous efficacy of percutaneous nitroglycerin was evaluated in 24 patients with coronary heart disease. Groups of 8 patients each received one, two or four patches (nitroglycerin liberation 5 mg per patch within 24 hours). Prior to application and after 1 and 2 hours cardiac frequency, arterial and pulmonary arterial pressures and exercise tolerance were assessed. Cardiac frequency and arterial pressure showed no relevant changes after application of patches. The mean pulmonary arterial pressure decreased after application of one or two plasters by 18.5 and 22.2% at rest and by 12.7 and 21.1%, respectively, during exercise. The working capacity showed a trend towards improvement only. With four nitroglycerin patches the mean pulmonary arterial pressure at rest was lower by 26.2% and during exercise by 39.1%. The working capacity rose significantly by 48.7%. Comparison of these effects with oral single dosage of 20 mg 5-isosorbide mononitrate (ISMN) showed that two simultaneously administered plasters did not achieve efficacy of 20 mg 5-ISMN, four plasters, however, were more effective.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::27087e52b581181eb33a5c0dfe249bdd https://doi.org/10.1055/s-2008-1069260 Zobrazit plný text záznamu