Hepatitis E virus infection as a direct cause of neuralgic amyotrophy
| Autor: | Mauro Silva, Christopher Doerig, Giorgio Zanetti, Roland Sahli, Vincent Aubert, Pinelopi Tsouni, Darius Moradpour, Sophie Cunningham, Thierry Kuntzer, Benoît Wicki |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology viruses medicine.disease_cause Gastroenterology 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cerebrospinal fluid Hepatitis E virus Physiology (medical) Internal medicine medicine Seroconversion Brachial Plexus Neuritis medicine.diagnostic_test business.industry virus diseases Polyradiculopathy Hepatitis E medicine.disease Virology digestive system diseases 030104 developmental biology Brachial Plexopathy Neurology (clinical) business Liver function tests 030217 neurology & neurosurgery |
| Zdroj: | Muscle & Nerve. 54:325-327 |
| ISSN: | 0148-639X |
| DOI: | 10.1002/mus.25096 |
| Popis: | Introduction: We describe a patient who developed neuralgic amyotrophy (NA) related to hepatitis E virus (HEV) infection. Methods: The patient underwent neurological and electrodiagnostic examinations, high-resolution analysis of serological changes, and HEV load profile, and was treated with intravenous immunoglobulin. Results: There was evidence of bilateral, asymmetric acute inflammatory cervical polyradiculopathy and possible brachial plexopathy. Positive serum anti-HEV IgM was followed by seroconversion to anti-HEV IgG positivity. A calculated anti-HEV antibody index was compatible with intrathecal synthesis, and HEV genotype 3 RNA was found in serum and cerebrospinal fluid (CSF). Liver function tests returned to normal within 6 weeks. Conclusions: Bilateral involvement of cervical nerve roots and/or plexus, elevated liver function tests, and abnormal CSF are typical features of HEV-associated NA. The pathogenesis involves possible immune-mediated mechanisms. However, our findings support the hypothesis that HEV-related NA is associated with direct infection. Muscle Nerve 54: 325–327, 2016 |
| Databáze: | OpenAIRE |
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