Usefulness of inflammatory and haemostatic markers to predict short-term risk for death in middle-aged ischaemic stroke patients
| Autor: | Loukianos S. Rallidis, D. Kremastinos, G. K. Liakos, E. Krania, Demosthenes B. Panagiotakos, M. Vikelis |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
biology business.industry Vascular disease C-reactive protein General Medicine Thrombophilia medicine.disease Fibrinogen Surgery Brain ischemia Neurology Internal medicine D-dimer medicine Cardiology biology.protein Neurology (clinical) Risk factor business Stroke medicine.drug |
| Zdroj: | Acta Neurologica Scandinavica. 117:415-420 |
| ISSN: | 0001-6314 |
| DOI: | 10.1111/j.1600-0404.2007.00971.x |
| Popis: | Objectives – There is increasing evidence that inflammation and hypercoagulability play an important role in the pathophysiology of acute ischaemic stroke. We examined the in-hospital prognostic value on mortality of C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha), fibrinogen and D-dimer in middle-aged ischaemic stroke patients. Materials and methods – We recruited 231 consecutive patients 18 mg/l and fibrinogen levels >490 mg/dl were the optimal points that discriminated those who died from the rest. Conclusions – CRP and fibrinogen levels can predict independently the risk of early death in middle-aged ischaemic stroke patients emphasizing the role of inflammation and coagulation in the evolution of ischaemic stroke. |
| Databáze: | OpenAIRE |
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